Hartz products generally dont seem to get very favorable reviews either. If your Collie doesnt play like that, you should be fine. Best of luck with your new girl! Sentinel comes in a chewable pill form and protects against multiple internal parasites (heartworms, whipworms, hookworms, and roundworms) as well as the development of flea eggs. After logging in you can close it and return to this page. Mary. They both have tolerated Bravecto very well.no noticeable side effects. This monthly chewable is recommended for 8 weeks and older dogs, weighing 2.8 lbs or more. I think this is a couple years old. We recently switched our dogs to a new product called Simparica Trio. I need to pivot, and looking at Frontline there are two new Frontline products to combat the flea resistance. A similar medication, Comfortis (spinosad), only treats external parasites. Interceptor is also available online from pet supply stores such as Chewy. (Im guessing based on your question about Prinovox that youre not in the US, so in case Frontline goes by a different name where you are just look for the active ingredients Fipronil and S-methoprene. Mar 2013. Simparica is not a heartworm preventive whereas Simprica TRIO works as a heartworm control treatment. Nexgard Spectra. I cant promise that it will be 100% effective, and one or two ticks may still latch on but Ive seen zero ticks on my dogs since I started using the Natural Chemistry spray in conjunction with Frontline Plus. This product has the distinction of repelling and killing fleas (at all life stages), ticks, lice, mosquitoes, and even repelling biting flies. I have never even heard of the latter and do not believe they exist in Canada. Study free flashcards about heartworm extra note created by Dkamplain to improve your grades. SIMPARICA TRIO (sarolaner, moxidectin, and pyrantel chewable tablets) is a flavored, chewable tablet for administration to dogs 8 weeks of age and older. What do you know about this? Thanks much for the info before I bought anything! a thorough study conducted on MDR1-affected dogs, this study conducted on twenty MDR1-affected Collies, the Washington State University of Veterinary Medicine, safe for use with anthelmintics like heartworm meds, Some swear by food grade DE (diatomaceous earth) as a natural dewormer. The Vet is too expensive! Dogs, 6 Month Supply. How can I prevent my dog from getting ticks? Vectras brag is that it repels and kills fleas, five kinds of ticks, flies, mosquitoes, and mites; however, its use is not worth its risk. Advantage takes care of fleas at all life stages and is even supposed to kill them on contact, and it also covers lice. That indicates it is a strong chemical compound, so do watch for skin irritation. Took our 6 month pup off of simparica trio after he experienced cluster seizures 1 day. Thank you for this. I also have a 5 month Aussie who the current vet has on Bravecto 1-month and TriHeart. Happy to help! Trish. (Your vet or a pet store associate may recommend otherwise, but bear in mind that they also want to make money.). What an awesome article. Is Simparica trio safe for dogs with the MDR1 gene? Material name: Simparica Trio Version #: 01 Issue date: 07-01-2019 SDS US. It is supposed to repel mosquitoes as well but I am very nervous about not using a heart worm preventative. If you think about it, come back here and let me and other readers know what worked best for you! We have always used Frontline Plus, but it has recently started causing dandruff on our dog, and it makes his coat greasy. I asked the vet for an alternative and was recommended Seresto collar or Vectra 3D. It prevents flea and tick infestations. Im glad you found this information helpful. Until progress is achieved in ongoing studies, adjustments are made to the medications themselves, and the FDA warning is lifted, Ill have to leave Bravecto in the caution category. Eliminate fleas before they lay eggs. Simparica Trio prevented microfilaremia in all dogs and was highly effective (97.2%) and significantly better than either Heartgard Plus (8.5%) or Interceptor Plus (35.9%) in preventing the development of the ZoeLA ML-resistant heartworm strain when administered for six consecutive months in this co they have caused seizures and death in dogs and even some reactions in humans who sleep with their dogs in their beds. Maybe regular Interceptor would be fine since it doesnt contain Praziquantel, but its difficult to say exactly what your dog is reacting to. Regardless of the heartworm product you choose, as the Institute of Pharmacology and Toxicology says, treatment of MDR1 mutant dogs with macrocyclic lactones in general requires particular caution. It really boils down to weighing the benefits of medications against the risks from internal parasites. Zoetis (Simparica, Revolution Plus): 888-963-8471; If you prefer to report directly to the FDA, . Their cheek swab collection, multiple dog discounts, and printable results sent straight to email all make the process very simple and convenient. That is my concern. First, I want to thank you for the time and effort that went into writing this article. The main goal of this medication, according to the FDA, is; This organic powder is great for a variety of uses. Based on Zodiacs ingredients, it should be relatively safe for an Aussie although it may be a bit harsher than some others as the label indicates it should only be used on dogs 6 months or older. The active ingredients of SimpleGuard 3 are the same as Vectra 3D: dinotefuran, pyriproxifen, and permethrin. Any thoughts? Excellent research and well written article! Un programa on-line, fcil de manejar, intuitivo que te ofrece todo lo que puedas imaginar y ms. Id like to have a Border Collie one day, but as I have some health issues Im not sure I could keep up with one. Some parts of the U.S. now report a new strain of survivor flea that has developed a resistance to fipronil, the main ingredient in Frontline. (I have to give them baths with a very mild or medicated shampoo.) . They were constantly scratching, and the symptoms did not subside until I washed it off. Hi Debbie! ? These generics include Tri-Heart Plus, Iverhart Plus, and Nuheart. There werent as many seizures reported as with Nexgard, but it did have several more reported than Bravecto. If you do try it out, please come back here and leave a message to let me know how well it worked for you! Simparica Trio (sarolaner, moxidectin and pyrantel) tablets for dogs; . (There are other places, but none more affordable that Ive found.) The drawback of using them is that they generally dont take care of as large a range of parasites as using two separate medications does. Effective against ticks that may carry debilitating diseases like ehrlichiosis, anaplasmosis, and rickettsiosis 2. Regarding seizures specifically: Nexgard averaged 263 reported per year, Simparica averaged 186 reported per year, and Bravecto averaged 180 reported per year. Appreciated!!! (If you order online, keep in mind that the company will first have to contact your veterinarian for a prescription to be issued, which may slightly delay the shipping time.). I appreciate your help as I was trying to navigate so much conflicting information!! . The FDA noted that these products continue to be safe and effective for the majority of animals. (My dogs dont groom each other or really play that way now that theyre older and settled, so I feel comfortable using topicals now.) . If you havent yet tried Interceptor for heartworm prevention, I would suggest that for you. Be prepared to answer questions about whether your dog had a previous history with seizures, has any drug sensitivities, if anything else could possibly have triggered a seizure, and if she has had any seizures since the collar was removed. For those of you who want proof or a more in-depth explanation of whyIve given each medicine its label, feel free to read the commentary under each product and even follow the embedded links for further reading. Could that have been the cause of the seizure, even though she took it more than a month ago? (One such knockoff, Pet Armor Plus, is even available at Walmart.). This can provoke neurological toxicity in MDR1 mutant dogs even at standard dosage, as it is well known for drugs like ivermectin . Basically, while the FDA has not pulled these drugs from the market, it has asked the product manufacturers to add precautions to their labels while it continues to monitor information submitted by veterinarians, the companies themselves, and individual product users. After 1 emergency vet visit and a number of consultations with our primary care vet, we took him off simparica. (The Environmental Protection Agency is responsible for approving external flea and tick products.) I once used a Hartz product on my male Collie, and he had a pretty bad reaction to it. Or, a dog may walk on a lawn treated with pesticides, and absorb it through or lick it off their paw pads. Is Simparica Trio safe for dogs with MDR1? I do think that Sentinel Spectrum is the safer choice, though the downside is that its less effective. We love her. Im hoping to get a Smoothie myself in the future. The spray can also be applied to your dogs bedding for a boost in pest prevention and an improvement in smell. Kudos to you for going out of your way to manage your Collies health, and good luck as you continue to search for what will work best for her! I have a 8 yr old MAS/Aussie who is MDR1 +/+ and I have her on Trifexis and have had no issues to date. Based on my findings, Im not convinced of its superior safety. To make dosing easy, it's available for dogs in six sizes based on body weight range: Gold: 2.8-5.5 pounds. . Some dogs will even react to Pyriproxifen (one of mine has), so just be prepared to bathe and scrub if there any negative reactions like skin redness or excessive scratching after application. The product insert states Do not use this product on debilitated, aged, medicated, pregnant or nursing dogs, or dogs known to be sensitive to pesticide products., If you live in a seasonal region where you actually experience winter complete with freezing temperatures and snow, and your pets have been on regular pest preventive products, you can give them a break from chemicals for a few months while the insects are dormant. Simparica 5 mg chewable tablets for dogs 1.3-2.5 kg Simparica 10 mg chewable tablets for dogs >2.5-5 kg . Eur. With seizures it's tough to pinpoint the cause (without extensive testing), so vet recommended . tratados. The login page will open in a new tab. Also, Permethrin is one of the active ingredients in K9 Advantix II, an effective spot-on product Ive used on my Aussie mix with no ill effects. LIST OF DRUGS THAT CAUSE SENSITIVITY TO DOGS WITH MDR1 MUTATION. Honestly, Id use it even if it was completely ineffective, because it makes my dogs smell delicious. Normally I would advise to just listen to your vet, but in this case I think I have to say listen to your instincts also especially since youre the one living with your pet and making the observations. Simparica TRIO Chews for Dogs 44-88 lbs (20.1-40 kg) - Green 6 Chews (11/2024 Expiry) Was: $115.99. (357 reviews) Simparica. Several clinical trials funded by Zoetis published shortly after drug approval showed impressive results concerning safety and incidence of adverse effects in dogs. Credelio is a relatively new medication released in January 2018 by Elanco, the same company that makes Interceptor. Many veterinary clinics keep some in stock for their clients, and it is also available at online stores like 1-800-PET-MEDS or Chewy. Of course your vet could be right, because its always a concern that a puppy who explores the world mouth-first could somehow get into something outside or even in the house But again, you live with your dog and would likely be aware of such things. Im sincerely grateful!! However, I think your plan to take the collar on and off was probably the best way to give it a safe trial period. Thank you for the positive feedback. I hope you get this. Bottom line is that Simparica will probably be fine for your dog, but there is a slight risk that it wont. (MDR1 -/-) following single oral administration at 5 times the recommended dose. 4.11 Withdrawal period(s) Sarolaner is also a component of the combination drug Simparica Trio, which contains sarolaner, moxidectin, and pyrantel. Personally I use Frontline Plus and supplement weekly with a Natural Chemistry spray as a repellent, but I understand that might not be ideal for everyone depending on their situations. Thank you for the research and the detailed info on each product. She was obviously in discomfort. For the treatment and control of tick infestations with Amblyomma americanum (lone star tick) and Ixodes scapularis . According to the Vet UK website, Safety. These four ML compounds (ivermectin, moxidectin, selamectin, and milbemycin oxide) have been officially approved by the FDA (Federal Drug Administration) and tested safe for MDR1 dogs when administered at the recommended preventative dosage. And safe travels to you and Lola in the future. Hi there , thank you for putting this information up! Simparica is administered once a month as a flavored chewable. Microfilaria and adult heartworm antigen testing. As one holistic veterinarian explains: The Vectra 3D can have side effects which include extreme restlessness and jitteriness, described as anxiety or manic behavior. Sarolaner, sold under the brand name Simparica, is an ectoparasiticide veterinary medication for the treatment of flea and tick infestations in dogs. We actually live in New Hampshire and hike (off-leash) quite frequently. Since I live in Florida, Revolution is not the best choice for me as it only targets the dog tick. Demonstrated 98.9% effectiveness against existing tick infestations in 48 hours . Dogs with normal MDR1 genes can usually tolerate oral dosages as high as 2,500 mcg/kg of body weight before signs of toxicity are seen, while dogs with two copies of the defective MDR1 gene can tolerate only up to 100 mcg/kg of oral ivermectin. Good luck with the puppies, and I hope they get healthy soon. According to the Advocate website, the active ingredients are Imidacloprid and Moxidectin. These can come in a few different forms: monthly spot-on, a disposable collar, or a spray. Because of their similarity to Heartgard, Ive placed them in the same caution category. Thank you!! Nexgard and Simparica. Thanks Documented negative reactions were only provoked at higher-than-normal dosages and were comparatively mild, consisting of salivation, ataxia (dilated pupils), and depression. Our are both indoors and outdoors. 1x 10mg tablet for 5.6 to 11 pounds. Fleas were treated with effifax, active ingredient fipronil. Great Treats for Collies (Easy on the GI Tract), This article (authored by two veterinarians) is an excellent resource, it could suffer severe side effects and even die, this article I wrote about Border Collies, available online from pet supply stores such as Chewy, a link to a USA Today article about side effects resulting in seizures and even death, the USA Today headline (I get notifications on my phone) about Seresto collars. Thank you for all the research, it was all so helpful. However, in such sensitive breeds (which may include, but not necessarily limited to, Collies and related breeds), the recommended dose should be strictly observed. Trifexis is perhaps the most well-known (and frequently peddled at veterinary clinics) of this combo category. The MDR1 mutation is believed to occur in approximately 50% of Australian Shepherds. GSD is an abbreviation for German Shepherd Dog , Thankyou so much for your articleso much great infoI have a 7 month mini Aussieon Symparticabut not feeling good about itshe hasnt been tested for MRD1 but I know I have to change it upthankyou again , Youre very welcome, and good luck with your pup! IMPORTANT SAFETY INFORMATION: NexGard is for use in . Please tell me which is the safest! Happy to be of help! The flavored, chewable tablets were consumed . Although it would be very hard to determine exactly which component of a combination medication your Collie is reacting to, your girl might be less likely to have a reaction to Interceptor (regular, not Plus), as it only has one active ingredient as opposed to the two active ingredients in Sentinel. I did write this article a couple of years ago; but I have updated it several times since most recently after information came out about some fatal reactions to Seresto collars. Some remain safe, others should be avoided. Giardia can be passed to and cause diarrhea in humans. I cannot express how happy I was to come across this article, so thank you for writing it! Super useful research. Dosage is at .91mg/lb (2mg/kg) Simparica should only be administered to dogs 6 months of age and older. It has been demonstrated to be safe for puppies as young as 8 weeks old weighing 2.8 pounds or more. As an aussie, I like to assume he's an MDR1 carrier therefore can be reactive to certain meds. Thats what I plan to use in future, when my oldest dog reaches that point. The back label warns that it may be fatal for cats, and advises cats and dogs should be kept apart for 24 hours following application. Unacceptable for me) He is MDR1 clear. Simparica TRIO is a monthly chewable tablet that protects your dog against heartworm disease, five types of ticks, fleas, roundworms and hookworms. new post updates in monthly email newsletters. Key Features of Simparica Trio. But I do think K9 Advantix is a good choice for Collies who arent overly sensitive. I love that it quickly kills adult fleas andfour kinds of ticks: American dog tick, brown dog tick, lone star tick, and black-legged tick. Anyway, we have a lot of lyme disease here in Wisconsin so we need a good tick preventative. I just dont know what to do about heartworm treatment and wonder if Interceptor instead of Interceptor Plus would be a better option or more of the same. Any thoughts on either of these? It probably is the safest as it is aimed only at preventing heartworm. However, I officially can no longer recommend Seresto collars, since it is now known thatthey have caused seizures and death in dogs and even some reactions in humans who sleep with their dogs in their beds. I have a one year old Aussie mix. You might want to look at the information on Nexgard. Bear in mind that my opinion is by no means professional, but personally Id go with your first vets prescription. Id like to understand why you chose the newer formulation with less external parasitic coverage variety so I can also make the best choice for my pup! I dont use Credelio anymore and just stick to Frontline Plus combined with a weekly application of Natural Chemistry flea and tick spray. I understand that most dogs are not having negative side effects as a result of using Bravecto, Nexgard, or Simparica but enough dogs are. The vet thought he would be nice and put Advantage Multi on our cats. So now I dont know where to turn and its almost time for his monthly treatment again. The vet said at first that was not possible and checked with their pharmaceutical representative who said that was not possible. Thank you! From the time that the collar went on the market in 2012 until 2020, the EPA (Environmental Protection Agency) received 1,698 reports of deceased pets. His food hadnt changed, so Im nearly certain it was an adverse reaction to the Credelio. 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For approving external flea and tick products. ) a very mild or shampoo. Products generally dont seem to get very favorable reviews either and absorb through... Be nice and put advantage Multi on our cats a heart worm preventative recently switched our dogs to a product! ( MDR1 -/- ) following single oral administration at 5 times the recommended dose applied! And frequently peddled at veterinary clinics keep some in stock for their clients and!